Endocrine Abstracts

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age often associated with insulin resistance, diabetes mellitus, hyperandrogenism, dislipidemia, obesity and hypertension, pathological conditions predisposing to high cardiovascular risk. Insulin resistant subjects may have higher plasma renin activity and it is well known that aldosterone plays a well-recognized role in the pathophysiology of hypertension and in the development of...

Background and aim: Epicardial fat (EF) is a metabolically active organ as well as visceral fat (VF). EF has been recognized as a potential additional marker of cardiac risk in obesity and type 2 diabetes. This study wants to assess the relation between EF and VF and the correlation with nutritional and hormonal parameters.Material and Methods: Fifty-nine overweight/obese women were enrolled in the study. All women underwent anthropometric measurements, ...

Background: Subclinical Cushing’s syndrome (SCS) is defined as alterations in hypothalamic–pituitary–adrenal axis without classic signs or symptoms of glucocorticoid excess. It is still controversial whether SCS leads to metabolic and cardiovascular diseases, and if the degree of subclinical hypercortisolism may predict these clinical outcomes.Aim: To evaluate the prevalence of hypertension, type-2 diabetes (T2D), coronary heart disease (C...

Polycystic Ovary Syndrome (PCOS) is currently believed a common endocrine-plurimetabolic disorder often associated to insulin resistance, diabetes mellitus, hypertension, hyperandrogenism, dyslipidemia and obesity, pathological conditions predisposing to high cardiovascular risk. Oxidative stress and endothelial dysfunction could represent early mechanisms of the cardiovascular risk in patients with PCOS. In order to confirm this hypothesis, 25 young (23.8±1.3 yr), over-w...